USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: IQGA2_HUMAN USC-OGP 2-DE database:  IQGA2_HUMAN IQGA2_HUMAN General information about the entry View entry in simple text format Entry name IQGA2_HUMAN Primary accession number Q13576 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ras GTPase-activating-like protein IQGAP2;. Gene name Name=IQGAP2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0031: pI=4.76; Mw=75144 SPOT OGP-0033: pI=4.80; Mw=74826 Cross-references UniProtKB/Swiss-Prot Q13576; IQGA2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IQGA2_HUMAN Primary accession number Q13576 Secondary accession number(s) A8K4V1 B7Z8A4 J3KR91 Sequence was last modified on  March 23, 2010 (version 4) Annotations were last modified on  March 15, 2017 (version 164) Name and origin of the protein Description RecName: Full=Ras GTPase-activating-like protein IQGAP2; Gene name Name=IQGAP2 Encoded on Name=IQGAP2 Keywords 3D-structure; Alternative splicing; Calmodulin-binding; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U51903; AAB37765.1; -; mRNA EMBL AY351902; AAQ81291.1; -; mRNA EMBL AK291066; BAF83755.1; -; mRNA EMBL AK303054; BAH13890.1; -; mRNA EMBL AC025188; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC026706; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC026725; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC093251; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC112173; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS CCDS34188.1; -. [Q13576-1]; . CCDS CCDS68897.1; -. [Q13576-2]; . CCDS CCDS68898.1; -. [Q13576-3]; . RefSeq NP_001272389.1; NM_001285460.1; . RefSeq NP_001272390.1; NM_001285461.1; . RefSeq NP_001272391.1; NM_001285462.1; . RefSeq NP_006624.2; NM_006633.3; . UniGene Hs.291030; -; . PDB 3IEZ; X-ray; 1.50 A; A/B=1476-1571 PDB 4EZA; X-ray; 1.50 A; A/B=1476-1571 PDB 5CJP; X-ray; 2.60 A; E/F=875-1258 PDBsum 3IEZ; -; . PDBsum 4EZA; -; . PDBsum 5CJP; -; . ProteinModelPortal Q13576; -; . SMR Q13576; -; . BioGrid 116004; 18; . DIP DIP-27542N; -; . IntAct Q13576; 18; . MINT MINT-5004527; -; . STRING 9606.ENSP00000274364; -; . iPTMnet Q13576; -; . PhosphoSitePlus Q13576; -; . BioMuta IQGAP2; -; . DMDM 292495090; -; . OGP Q13576; -; . EPD Q13576; -; . MaxQB Q13576; -; . PaxDb Q13576; -; . PeptideAtlas Q13576; -; . PRIDE Q13576; -; . DNASU 10788; -; . Ensembl ENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]; . Ensembl ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]; . Ensembl ENST00000502745; ENSP00000426027; ENSG00000145703. [Q13576-3]; . GeneID 10788; -; . KEGG hsa:10788; -; . UCSC uc003kek.5; human. [Q13576-1]; . CTD 10788; -; . DisGeNET 10788; -; . GeneCards IQGAP2; -; . HGNC HGNC:6111; IQGAP2; . HPA CAB004241; -; . HPA HPA037403; -; . HPA HPA037404; -; . MIM 605401; gene; . neXtProt NX_Q13576; -; . OpenTargets ENSG00000145703; -; . PharmGKB PA29911; -; . eggNOG KOG2128; Eukaryota; . eggNOG COG5261; LUCA; . GeneTree ENSGT00600000084379; -; . HOGENOM HOG000004842; -; . HOVERGEN HBG052143; -; . InParanoid Q13576; -; . KO K05767; -; . OMA KGGEMQI; -; . OrthoDB EOG091G00ET; -; . PhylomeDB Q13576; -; . TreeFam TF313078; -; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-6798695; Neutrophil degranulation; . ChiTaRS IQGAP2; human; . EvolutionaryTrace Q13576; -; . GeneWiki IQGAP2; -; . GenomeRNAi 10788; -; . PRO PR:Q13576; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000145703; -; . CleanEx HS_IQGAP2; -; . ExpressionAtlas Q13576; baseline and differential; . Genevisible Q13576; HS; . GO GO:0015629; C:actin cytoskeleton; TAS:ProtInc; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0030175; C:filopodium; IDA:UniProtKB; . GO GO:0030027; C:lamellipodium; IDA:UniProtKB; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0005902; C:microvillus; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0030667; C:secretory granule membrane; TAS:Reactome; . GO GO:0003779; F:actin binding; TAS:ProtInc; . GO GO:0051015; F:actin filament binding; IDA:UniProtKB; . GO GO:0071933; F:Arp2/3 complex binding; IDA:UniProtKB; . GO GO:0005516; F:calmodulin binding; IPI:UniProtKB; . GO GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc; . GO GO:0005547; F:phosphatidylinositol-3; 4; 5-trisphosphate binding IDA:UniProtKB . GO GO:0048365; F:Rac GTPase binding; IDA:UniProtKB; . GO GO:0017048; F:Rho GTPase binding; IDA:UniProtKB; . GO GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IDA:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . GO GO:0070493; P:thrombin-activated receptor signaling pathway; IDA:UniProtKB; . CDD cd00014; CH; 1; . Gene3D 1.10.418.10; -; 1; . Gene3D 1.10.506.10; -; 2; . InterPro IPR001715; CH-domain; . InterPro IPR000048; IQ_motif_EF-hand-BS; . InterPro IPR000593; RasGAP_C; . InterPro IPR023152; RasGAP_CS; . InterPro IPR001936; RasGAP_dom; . InterPro IPR008936; Rho_GTPase_activation_prot; . InterPro IPR001202; WW_dom; . Pfam PF00307; CH; 1; . Pfam PF00612; IQ; 2; . Pfam PF00616; RasGAP; 1; . Pfam PF03836; RasGAP_C; 1; . SMART SM00033; CH; 1; . SMART SM00015; IQ; 3; . SMART SM00323; RasGAP; 1; . SUPFAM SSF47576; SSF47576; 1; . SUPFAM SSF48350; SSF48350; 2; . PROSITE PS50021; CH; 1; . PROSITE PS50096; IQ; 3; . PROSITE PS00509; RAS_GTPASE_ACTIV_1; 1; . PROSITE PS50018; RAS_GTPASE_ACTIV_2; 1; . PROSITE PS01159; WW_DOMAIN_1; 1; . PROSITE PS50020; WW_DOMAIN_2; 1; .

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